Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetHuman leukocyte elastase (HLE)

Product does not compete with ATP.

Target K_i: 10 µM against human leukocyte elastase (HLE)

General description

A potent irreversible inhibitor of human leukocyte elastase (HLE)(K_i = 10 µM). Protects against lung injury induced by instillation of elastase.

A potent inhibitor of human leukocyte elastase (HLE) (K_i = 10 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Fletcher, D.S., et al. 1990. Am. Rev. Respir. Dis.141, 672.Stein, R.L., and Trainor, D.A. 1986. Biochemistry 25, 5414.Powers, J.C., et al. 1977. Biochim. Biophys. Acta 485, 15.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Sequence

MeOSuc-Ala-Ala-Pro-Val-CMK

Warning

Toxicity: Standard Handling (A)